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MEDICAL / Hematology
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Acute leukaemia in adults
Suspect acute leukaemia in patients with anaemia, neutropenia, thrombocytopenia and associated sy...
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Anaemia in children
Leukaemias and acute haemolytic crises should be readily identified as these conditions require i...
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Assessment and treatment of a patient with bleeding diathesis
In primary care, the principal aim should be to identify patients whose bleeding diathesis could ...
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Assessment of anaemia in adults
Anaemia is the most common blood disorder encountered in outpatient care, iron deficiency anaemia...
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Blood transfusion: indications, administration and adverse reactions
Donated blood is not transfused to the recipient until it has been processed into its separate bl...
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Bone marrow examination
Bone marrow examination is an easy and inexpensive outpatient examination. It is necessary for co...
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Bruises and purpura in children
In a child with recurrent or prolonged bleedings, bleeding at several sites, or bleeding being no...
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Chronic lymphocytic leukaemia (CLL)
Chronic lymphocytic leukaemia is a slowly progressing (chronic) malignant blood disease where mor...
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Deep vein thrombosis
As many as half of all cases of deep vein thrombosis (DVT) develop without clinical symptoms, and...
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Easy bruising, petechiae and ecchymoses
Everybody has occasional bruising after minor trauma or even without a noticed trauma at all. The...
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Elevated ESR (hypersedimentation)
An erythrocyte sedimentation rate (ESR) value is principally dependent on the concentration of pl...
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Eosinophilia
Eosinophils normally account for 1–5% of leucocytes in peripheral blood in adults. The refe...
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Erythrocytosis
Erythrocytosis refers to an elevation of the total number of red cells in blood. In practical ter...
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Essential thrombocythaemia (ET)
Essential Thrombocythaemia is a chronic myeloproliferative haematological malignancy characterize...
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Haemochromatosis
In hereditary haemochromatosis, disturbed regulation of iron absorption causes accumulation of ir...
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Haemolytic anaemia
A reticulocyte count (erythrocytes/blood) is a first-line investigation in anaemia; it differenti...
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Hereditary coagulation factor deficiencies
A general practitioner should be aware of the existence of all the patients in his/her area who h...
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Inherited thrombophilia
Inherited thrombophilia increases the likelihood of venous thrombosis. The highest risk is associ...
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Iron deficiency anaemia
The majority of cases of microcytic anaemia (MCV < 80 fl) are caused by iron deficiency. ...
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Leucocytopenia
The majority of white blood cells are either neutrophils (band cells and polymorphonuclear granul...
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Leucocytosis
Diagnose a severe infection as the cause of leucocytosis immediately and arrange treatment withou...
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Lymphomas
Lymphomas form a heterogeneous group of diseases as regards aggressiveness, need of care and prog...
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Macrocytosis (increased MCV)
Mean corpuscular volume or MCV denotes the average red blood cell volume. The normal reference ra...
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Megaloblastic anaemia
Suspect megaloblastic anaemia if the patient presents with macrocytic anaemia, i.e. increased ery...
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Multiple myeloma (MM)
Affects primarily middle-aged and elderly patients.Recognize complications that require prompt in...
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Polycythaemia vera (PV)
The major goal of the treatment is to prevent thrombotic complications and haemorrhages. The amou...
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Retinal venous thrombosis
The second most common circulatory disturbance of the ocular fundus after diabetic retinopathy Th...
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Secondary anaemia
Exclude "specific" anaemias (iron deficiency, vitamin deficiency, haemolysis, acute hae...
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Thalassaemias
Thalassaemias (a deficiency of globin chains) must be differentiated from other haemolytic diseas...
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Thrombocytopenia
Stop drugs possibly causing thrombocytopenia unless vitally indicated. If the thrombocytopenic pa...
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Thrombocytosis
The blood platelet or thrombocyte concentration varies between individuals but remains rather con...
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Tumours of haematopoietic and lymphoid tissues: general guidelines
The possibility of a malignant haematological disorder should be kept in mind when the patient&rs...
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Waldenström's macroglobulinaemia (WM)
Remember Waldenström's macroglobulinaemia as a rare cause of a high ESR. In most cases a...
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Warfarin therapy
Warfarin reduces the activity of both vitamin K dependent clotting factors and the natural antico...
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