Frontotemporal lobar degeneration

Frontotemporal lobar degeneration is a progressive memory disease with three typical symptom pictures: frontotemporal dementia progressive nonfluent aphasia semantic dementia.In 30–40% of the patients the disease has familial occurrence.The most common genetic aetiology associated with frontotemporal lobar degeneration is a non-coding repeat expansion of the C9ORF72 (chromosome 9 open-reading frame 72) gene. Frontotemporal lobar degeneration may have several underlying neuropathological subtypes, and therefore there are no specific biomarkers for the disease available.