Paget's disease of bone (osteitis deformans)

Paget’s disease is a chronic metabolic disorder of unknown aetiology that affects the skeleton. It is characterised by rapid local bone resorption followed by chaotic new bone deposition, which leads to abnormally structured bone at one or several sites in the skeleton.Lesions are most typically found in the skull, spine, pelvis and long bones of the lower extremities. Local symptoms include pain, fractures, nerve entrapments and bone tumours. Plasma alkaline phosphatase concentration is increased.