Amyloidosis is a heterogenic group of diseases which are caused by amyloid deposited in various body tissues and organs. Amyloid is a protein-containing fibrillar material deposited in the extracellular space. Amyloid has an affinity for Congo red dye and appears green when viewed in polarised light. The aetiology of amyloidosis may be hereditary or acquired, and the amyloid deposits may be either localised or systemic. These clinical forms are further classified according to the biochemical composition of the amyloid fibrils. The clinical manifestations of amyloid accumulation are manifold and their recognition may be difficult.