Usually begins with memory disturbances: the patient fails to learn new things. Clinical diagnosis is correct in about 90% of cases. The progress of the disease is usually slow but steady, although periods of slower and faster deterioration may occur. Disease duration from the first symptoms to death is approximately 12 years (range from 2 to over 20 years). The most common immediate cause of death is aspiration pneumonia. Medication offers some help by improving functional capacity and alleviating cognitive and behavioural symptoms. However, not all patients benefit from medication and the effect may reduce over time. No curative medication or medication to prevent the progress of the disease is available so far.