Waldenström's macroglobulinaemia (WM)

Remember Waldenström's macroglobulinaemia as a rare cause of a high ESR. In most cases a long-term disease; progression may be very slowBasically a lymphoma disease (lymphoplasmacytic lymphoma); defined as WM when M component of IgM class is detected Clinical picture is characterized by symptoms of cytopenias and immunodeficiency, by extramedullary tumour infiltrates and by hyperviscosity symptoms.No osteolytic lesions