Hereditary angioedema (HAE) and ACE inhibitor-induced angioedema

Consider the possibility of hereditary angioedema (HAE) in the differential diagnosis of anaphylactic reaction if the patient has, or has had episodes of mucocutaneous oedema or bouts of abdominal pain or bouts of headache or a family history of HAE. Remember that angioedema is a possible adverse effect of ACE inhibitors.