Demonstration of gonococcal nucleic acid in first void urine is suitable for screening.Culture is the basic diagnostic method and it also provides determination of antimicrobial sensitivity. It is obtained in clinical suspicion of gonorrhoea or if the nucleic acid detection test is positive.Ceftriaxone is the drug of choice due to increased resistance to quinolones.Decreased sensitivity to ceftriaxone has been reported in some parts of the world.Gonorrhoea should not be treated with oral antimicrobials if the strain is not known to be sensitive to ciprofloxacin.